Neurobehavioral Genetics: Methods and Applications

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Byron C. Jones, Pierre Mormede
CRC Press, 2002 M01 1 - 416 páginas
Neurobehavioral Genetics: Methods and Applications covers classic and contemporary approaches to the study of the brain and behavior, including basic and clinical research. This book is designed as a reference for investigators wishing to incorporate genetic methods into neurobehavioral research. A broad spectrum of methods are integrated, unlike any other publication currently in print.
Neurobehavioral Genetics: Methods and Applications presents different models, from invertebrates to genetically defined mammals.
Introductory chapters demonstrate the scope and power of genetic methods that can be applied to neurobehavioral research from statistical methods and linkage analysis to contemporary molecular genetic approaches to search for candidate genes.
The second half of the book covers the applications of quantitative and molecular genetics in basic and clinical research. Topics covered include animal behavior and neurobiology and human clinical problems including neurodegenerative diseases and psychiatric disorders.
 

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Contenido

A Retrospect on Neurobehavioral Genetics
1
An Introduction to Quantitative Genetics
13
Planning Genetic Experiments Power and Sample Size
31
Classical Linkage Analysis
43
Neurogenetics Mendelian Genetics SingleGene Effects and Some of Their Complicating Factors
59
Quantitative Trait QTL Mapping
69
From QTL Detection to Gene Identification
77
Knockouts Constitutive Inducible or Tissue Specific The Examples of 5HT Receptors
93
Natural Genetic Variation of Hippocampal Structures and Behavior
217
Human Neurogenetics Neurodegenerative Diseases
237
Schizophrenia Study of a Genetically Complex Phenotype
247
Genetics of Autism and Its Place in an Integrated Clinicobiological Approach
265
Genetic Basis of Mental Retardation
275
Aggression Concepts and Methods Relevant to Genetic Analyses in Mice and Humans
293
Genetics and Emotional Behaviors Experimental Studies
301
Pharmacogenetic Selection
319

Behavioral Phenotyping of Transgenic and Knockout Mice
105
Animal Models in Neurobehavioral Genetics Methods for Estimating Genetic Correlation
121
Human Family Studies
141
The Twin Method
151
Detecting and Measuring GeneEnvironment Interaction in Human Temperament Aggressovoty and Personality Deviation Conduct Disorder Antisoci...
163
Maternal Effects in Behavior Genetic Analysis
187
Cerebellar Functions A Behavioral Neurogenetic Perspective
201
Psychopharmacogenetics of Alcohol
329
Pharmacogenetics of Drugs of Abuse
341
Genetic Analysis of Food Search Behavior in the Fruit Fly Drosophila melanogaster
357
Genetic Analysis of Drosophila Sexual Behavior
365
Genetic Analysis of Behavior in the Nematode Caenorhabditis elegans
373
Index
383
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